Abstract Functional brain imaging technology has developed rapidly in recent years. On the one hand, high-field 7-Tesla magnetic resonance imaging (MRI) has excelled the limited spatial resolution of 3-Tesla MRI, allowing us to enter a new world of mesoscopic imaging from the macroscopic imaging of human brain functions. On the other hand, novel optical pumping magnetometer-magnetoencephalography (OPM-MEG) has broken down the technical barriers of traditional superconducting MEG, which brings imaging of neuronal electromagnetic signals from cortical imaging to whole-brain imaging. This article aims to present a brief introduction regarding the development of conventional MRI and MEG technology, and, more importantly, to delineate that high-field MRI and OPM-MEG complement each other and together will lead us into a new era of functional brain imaging.