Abstract This chapter is dedicated to motor disorders, first and foremost Parkinson’s disease, the area together with pain where most of the knowledge about the mechanisms of the placebo effect comes from. The placebo effect in Parkinson’s disease is mediated by dopamine release in the striatum and is associated with changes in activity of neurons in the subthalamic nucleus, substantia nigra pars reticulata, and motor thalamus. Deceptive verbal instructions about changes in drug dosage can affect the pharmacological effect of levodopa in the treatment of Parkinson’s disease. The therapeutic effects of deep brain stimulation are powerfully modulated by placebos. Migraine is another disease of the nervous system that shows very high rates of improvement in patients who received placebo, although the mechanisms are little understood. Other neurological diseases, like epilepsy, show improvements in placebo groups, but the mechanisms are not known.