Historical linguistics is a discipline with strong interdisciplinary connections to sociocultural anthropology, ethnohistory, and archaeology. While the study of language change and etymology can be traced back to ancient societies in the Mediterranean, the Middle East, and Asia, a number of important methodological approaches emerged in the late 18th century, when European scholars who were engaged in colonial administration set the foundations for research in Indo-European languages. Contemporary historical linguistics has maintained a focus on several large-scale questions, such as the origins of the language faculty; the classification and typology of the world’s languages; the time depth of major language changes; ancient writing systems; the impact of linguistic and cultural contacts on language change; the emergence of pidgins and creoles; the influence of colonial expansion and evangelization projects on language change; and the interface among literacy practices, language change, and the social order. This article outlines all of these important inquiries, with a particular stress on the sustained interaction among historical linguistics, anthropology, and ethnohistory. This survey has two focii: the first one is languages of the Americas, and the second one is ethnohistorical and philological methodology. This choice in focus conveys existing historical strengths and showcases our current knowledge about language contact and language change in the Americas.