Mechanisms of bacterial DNA replication restart
Copyright policy )Mechanisms of bacterial DNA replication restart
Multi-protein DNA replication complexes called replisomes perform the essential process of copying cellular genetic information prior to cell division. Under ideal conditions, replisomes dissociate only after the entire genome has been duplicated. However, DNA replication rarely occurs without interruptions that can dislodge replisomes from DNA. Such events produce incompletely replicated chromosomes that, if left unrepaired, prevent the segregation of full genomes to daughter cells. To mitigate this threat, cells have evolved 'DNA replication restart' pathways that have been best defined in bacteria. Replication restart requires recognition and remodeling of abandoned replication forks by DNA replication restart proteins followed by reloading of the replicative DNA helicase, which subsequently directs assembly of the remaining replisome subunits. This review summarizes our current understanding of the mechanisms underlying replication restart and the proteins that drive the process in Escherichia coli (PriA, PriB, PriC and DnaT).
- University of Wisconsin–La Crosse United States
- Vanderbilt University United States
- University of Wisconsin System United States
- University of Wisconsin–Madison United States
- University of Wisconsin School of Medicine and Public Health United States
DNA Replication, DNA, Bacterial, Models, Molecular, Models, Genetic, DNA Helicases, DNA-Binding Proteins, Bacterial Proteins, Protein Domains, Nucleic Acid Conformation, Survey and Summary, Protein Binding
DNA Replication, DNA, Bacterial, Models, Molecular, Models, Genetic, DNA Helicases, DNA-Binding Proteins, Bacterial Proteins, Protein Domains, Nucleic Acid Conformation, Survey and Summary, Protein Binding
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