KeyPathwayMinerWeb: online multi-omics network enrichment
Copyright policy )KeyPathwayMinerWeb: online multi-omics network enrichment
We present KeyPathwayMinerWeb, the first online platform for de novo pathway enrichment analysis directly in the browser. Given a biological interaction network (e.g. protein-protein interactions) and a series of molecular profiles derived from one or multiple OMICS studies (gene expression, for instance), KeyPathwayMiner extracts connected sub-networks containing a high number of active or differentially regulated genes (proteins, metabolites) in the molecular profiles. The web interface at (http://keypathwayminer.compbio.sdu.dk) implements all core functionalities of the KeyPathwayMiner tool set such as data integration, input of background knowledge, batch runs for parameter optimization and visualization of extracted pathways. In addition to an intuitive web interface, we also implemented a RESTful API that now enables other online developers to integrate network enrichment as a web service into their own platforms.
- Max Planck Society Germany
- Max Planck Institute for Informatics Germany
- Odense University Hospital Denmark
- University of Southern Denmark Denmark
Huntingtin Protein, Internet, Gene Expression Profiling, Computational Biology, Datasets as Topic, User-Computer Interface, Huntington Disease, Gene Expression Regulation, Case-Control Studies, Protein Interaction Mapping, Web Server issue, Humans, Gene Regulatory Networks
Huntingtin Protein, Internet, Gene Expression Profiling, Computational Biology, Datasets as Topic, User-Computer Interface, Huntington Disease, Gene Expression Regulation, Case-Control Studies, Protein Interaction Mapping, Web Server issue, Humans, Gene Regulatory Networks
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