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Nucleic Acids Research
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bNAber: database of broadly neutralizing HIV antibodies

Authors: Alexey M. Eroshkin; Andrew LeBlanc; Dana Weekes; Kai W. Post; Zhanwen Li; Akhil Rajput; Sal T. Butera; +2 Authors

bNAber: database of broadly neutralizing HIV antibodies

Abstract

The discovery of broadly neutralizing antibodies (bNAbs) has provided an enormous impetus to the HIV vaccine research and to entire immunology. The bNAber database at http://bNAber.org provides open, user-friendly access to detailed data on the rapidly growing list of HIV bNAbs, including neutralization profiles, sequences and three-dimensional structures (when available). It also provides an extensive list of visualization and analysis tools, such as heatmaps to analyse neutralization data as well as structure and sequence viewers to correlate bNAbs properties with structural and sequence features of individual antibodies. The goal of the bNAber database is to enable researchers in this field to easily compare and analyse available information on bNAbs thereby supporting efforts to design an effective vaccine for HIV/AIDS. The bNAber database not only provides easy access to data that currently is scattered in the Supplementary Materials sections of individual papers, but also contributes to the development of general standards of data that have to be presented with the discovery of new bNAbs and a universal mechanism of how such data can be shared.

Country
United States
Keywords

570, Protein Conformation, 610, Antigen-Antibody Complex, HIV Antibodies, Antibodies, Vaccine Related, Databases, Inhibitory Concentration 50, Information and Computing Sciences, Vaccine Related (AIDS), Databases, Protein, Neutralizing, Internet, Prevention, Protein, Biological Sciences, Antibodies, Neutralizing, Environmental sciences, Biological sciences, Infectious Diseases, Good Health and Well Being, VI. Genomic variation, diseases and drugs, Chemical sciences, Chemical Sciences, HIV/AIDS, Immunization, Infection, Environmental Sciences, Software, Biotechnology, Developmental Biology

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    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    Top 10%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Top 10%
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
71
Top 10%
Top 10%
Top 10%
Green
gold