The sequence of the 3′ non-coding region of the hexon mRNA discloses a novel adenovirus gene

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 1981 English Publisher:Oxford University Press (OUP)Journal:Nucleic Acids Research, volume 9, pages 1-17 (issn: 0305-1048, eissn: 1362-4962,

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Authors: G. Akusjarvi; J. Zabielski; M. Perricaudet; U. Pettersson;

doi: 10.1093/nar/9.1.1

pmid: 6259616

pmc: PMC326664

The sequence of the 3′ non-coding region of the hexon mRNA discloses a novel adenovirus gene

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Abstract

We report the sequence of a 1164 nucleotide long DNA segment, located between map positions 59.5 and 62.8 on the adenovirus type 2 genome. The sequence comprises the 701 nucleotides long 3' non-coding region of the hexon mRNA as well as several important processing signals. The sequence revealed unexpectedly that the 3' non-coding region of the hexon mRNA contains a 609 nucleotide long uninterrupted translational reading frame following a potential initiator AUG. A late 14S mRNA, corresponding to the open reading frame, could be identified by S1 nuclease mapping and electronmicroscopy. The mRNA shares a poly(A) addition site with the hexon and pVI mRNAs, and carries a leader sequence which is related, and probably identical, to the tripartite leader, found in late adenovirus mRNAs. The junction between the leader and the body of this novel mRNA is located within the coding part of the hexon gene.

Related Organizations

Institut Pasteur
France

Keywords

Microscopy, Electron, Base Sequence, Genes, Viral, Genetic Code, Adenoviruses, Human, DNA, Viral, Nucleic Acid Hybridization, DNA Restriction Enzymes, RNA, Messenger

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