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Nucleic Acids Research
Article . 1978 . Peer-reviewed
Data sources: Crossref
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Nucleic Acids Research
Article
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Nucleic Acids Research
Article . 1978
Data sources: Europe PubMed Central
https://dx.doi.org/10.1093/nar...
Article
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Enzymes from Micrococcus luteus involved in the initial steps of excision repair of spontaneous DNA lesions: uracil-DNA-glycosidase and apurinic-endonucleases

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 1978 English Publisher:Oxford University Press (OUP)Journal:Nucleic Acids Research, volume 5, pages 1,413-1,428 (issn: 0305-1048, eissn: 1362-4962, Copyright policy )
Authors: N V, Tomlin; O N, Aprelikova; L S, Barenfeld;

doi: 10.1093/nar/5.4.1413

pmid: 652527

pmc: PMC342088

Enzymes from Micrococcus luteus involved in the initial steps of excision repair of spontaneous DNA lesions: uracil-DNA-glycosidase and apurinic-endonucleases

Abstract

Uracil-DNA-glycosidase that releases free uracil from single-stranded or double-stranded deaminated DNA and poly d(A-U) has been partially purified from Micrococcus luteus. The enzyme has a molecular weight of about 16,000 and can be separated from uracil-endonuclease and endonucleases (AP-endonucleases) specific for apurinic and apyrimidinic sites. Uracil-DNA-glycosidase does not act on guanine residues opposite uracil in double-stranded DNA and on xanthine in deaminated DNA. The glycosidase generates apyrimidinic sites which can serve as substrate sites for different AP-endonucleases from M. luteus.

Related Organizations
Keywords

DNA, Bacterial, Apurinic Acid, Binding Sites, Deoxyribonucleases, Polydeoxyribonucleotides, DNA Repair, Deoxyuracil Nucleotides, Endonucleases, N-Glycosyl Hydrolases, Micrococcus

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
13
Average
Average
Top 10%
gold