Metabolic heterogeneity of nuclear poly (A)-containing RNA in mouse liver
Copyright policy )Metabolic heterogeneity of nuclear poly (A)-containing RNA in mouse liver
The analysis by the approach to equilibrium labeling method has shown that the poly(A)+ fraction of liver hnRNA is not a uniform class of molecules, but is comprised of two distinct subclasses with half-lives of 5 and 60 min, while the poly(A)- hnRNA was metabolically homogeneous and turned over with a rather uniform half-life of 30 min. The results suggest that (a) poly(A) synthesis and addition is not limiting for the rate of hnRNA processing, and (b) there is a correlation between the kinetics of mRNA appearance in the cytoplasm and kinetic behavior of their possible nuclear precursors.
- Academy of Medical Sciences United Kingdom
Male, Orotic Acid, Kinetics, Mice, Liver, Animals, RNA, RNA, Messenger, Poly A, Half-Life
Male, Orotic Acid, Kinetics, Mice, Liver, Animals, RNA, RNA, Messenger, Poly A, Half-Life
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