Intermolecular mRNA - rRNA hybridization and the distribution of potential interaction regions in murine 18s rRNA
Copyright policy )Intermolecular mRNA - rRNA hybridization and the distribution of potential interaction regions in murine 18s rRNA
Intermolecular hybridization experiments show that murine 18S rRNA and 28S rRNA are capable of forming stable hybrid structures with mRNA from genes p53, c-myc and c-mos from the same species. Both 5'-uncoding and coding oncogene p53 mRNA regions contain fragments interacting with rRNA. Computer analysis revealed 18S rRNA fragments complementary to oligonucleotides frequently met in mRNA, which are potential hybridization regions (clinger-fragments). The distribution of clinger-fragments along 18S rRNA sequence is universal at least for one hundred murine mRNA sequences analyzed. Maximal frequencies of oligonucleotides complementary to 18S rRNA clinger-fragments are reliably (2-3 times) higher for mRNA than for intron sequences and randomly generated sequences. The results obtained suggest a possible role of clinger-fragments in translation processes as universal regions of mRNA binding.
- Russian Academy
- Institute of Mathematical Problems of Biology Russian Federation
- Engelhardt Institute of Molecular Biology Russian Federation
- Russian Academy of Sciences Russian Federation
Models, Molecular, Mice, Base Sequence, Molecular Sequence Data, RNA, Ribosomal, 18S, Animals, Nucleic Acid Conformation, Nucleic Acid Hybridization, RNA, Messenger, Pattern Recognition, Automated
Models, Molecular, Mice, Base Sequence, Molecular Sequence Data, RNA, Ribosomal, 18S, Animals, Nucleic Acid Conformation, Nucleic Acid Hybridization, RNA, Messenger, Pattern Recognition, Automated
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