Catalytic activity of the nucleic acid component of the 1,4-α-glucan branching enzyme from rabbit muscles
Copyright policy )Catalytic activity of the nucleic acid component of the 1,4-α-glucan branching enzyme from rabbit muscles
2.5 S RNA, the nucleic acid component of the 1,4-alpha-D-glucan: 1,4-alpha-D-glucan 6-alpha-(1,4-alpha-glucano)-transferase from rabbit muscles, devoid of any protein, catalyses the branching reaction, as does the holoenzyme. The conclusion is drawn that 2.5 S RNA is a ribozyme. To get an insight into the significance of different parts of the molecule for the catalytic activity of 2.5 S RNA, a large fragment isolated from its partial RNAase A digest was investigated. This fragment which proved to be the middle part of polyribonucleotide chain containing all modified nucleotides exerts some catalytic activity, too.
- Russian Academy of Sciences Russian Federation
Kinetics, Glucosyltransferases, RNA, Ribosomal, 1,4-alpha-Glucan Branching Enzyme, Muscles, RNA Splicing, Animals, RNA, RNA, Catalytic, Rabbits
Kinetics, Glucosyltransferases, RNA, Ribosomal, 1,4-alpha-Glucan Branching Enzyme, Muscles, RNA Splicing, Animals, RNA, RNA, Catalytic, Rabbits
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