Over the past couple of decades there has been increased awareness that opioid use for postoperative pain in neonates may not result in the best outcomes for these patients. Concurrently, there has been an increased use of regional techniques for postoperative pain in the neonate, in particular epidural anesthesia. The most common technique has been an epidural block via a caudal catheter. Caudal catheters can be used for lumbar and thoracic epidural blocks. The caudal catheter technique allows for a theoretically safer means of placement than the classic, at-level, loss-of-resistance technique.