The term ‘genital disease’ refers to a spectrum of diseases. Certain systemic diseases preferentially affect mucous membranes. Local factors including warmth, occlusion, irritants, and friction are important and contribute to skin disease in this region and increase the risk of certain infections. Skin conditions may be difficult to diagnose, as they may have atypical appearances. Therefore, the diagnosis of disease in the anogenital region may be complex. This chapter will focus on the most common diseases seen in the dermatology clinic: lichen sclerosus, lichen planus, eczema, genital pain syndromes, and pre-malignant and malignant disease. Other less common dermatological conditions seen in this area will be briefly covered.