Deformities are important markers for congenital and hereditary neuromuscular disorders. For example, kyphosis, scoliosis, and pes cavus are common in Charcot-Marie-Tooth (CMT) disease and hereditary ataxias. Deformities such as high feet arches may also result from long-time weakness and asymmetry. Other types of deformities may be related to connective tissue pathology, which can be associated with neuromuscular disorders. Examples include multiple lipomatosis, scleroderma, and nephrogenic systemic sclerosis (NSS). Charcot joint is a result of lack of proprioceptive sensation and is usually associated with severe chronic neuropathy. Deformity of the nose can result from syphilis and leprosy. This chapter shows examples of these deformities and their treatments.