The phenomenology of PTSD has been established in the previous chapters to be an already broad domain that encompasses a myriad of interactions between brain systems. As our understanding of the disorder expands and yields new questions, so do the available options for treatment. The current chapter reviews the cognitive and behavioral interventions for PTSD and other anxiety disorders that have demonstrated efficacy in clinical trials, as well as a variety of emerging pharmacological interventions and the preclinical literature that has informed their development. The identification of biomarkers for PTSD is discussed in terms of their potential application as both potential predictors of the development of PTSD and of the outcome of interventions designed to treat it.