The incidence and severity of Clostridium difficile infections have increased over the past few decades. New challenges have developed in the treatment and prevention of both hospital- and community-acquired disease. As mentioned by Tamma and Sandora [ 1] in their recent review, many questions about C difficile management in children remain unanswered, forcing pediatricians to rely on adult studies for guidance. The following is a brief synopsis of a few recent publications that focused on C difficile infections, including comments regarding the implications within pediatric infectious diseases.