descriptionPublicationkeyboard_double_arrow_right Article 01 Oct 1981 English Publisher:Elsevier BVJournal:The Journal of Nutrition, volume 111, pages 1,833-1,838 (issn: 0022-3166,

Authors: L.F.M. van Zutphen; M. Den Bieman;

doi: 10.1093/jn/111.10.1833

pmid: 7288506

Cholesterol Response in Inbred Strains of Rats, Rattus norvegicus

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Abstract

A hypercholesterolemic diet fed to rats revealed significant interstrain differences in plasma cholesterol levels. Hyperresponding and hyporesponding strains could be distinguished from normoresponding strains within 3 weeks. The increase in plasma cholesterol level was more than 300 mg/100 ml in the hyperresponding strains BN/Cpb, SD/Cpb and WE/Z and less than 50 mg/100 ml in the hyporesponding strains S3/Cpb and SHR/Cpb. These differences were primarily genetically determined: the calculated coefficient of genetic determination (g2) of the response was 0.84. The response is not correlated with variation in plasma esterase or alkaline phosphatase isozyme patterns.

Related Organizations

Utrecht University
Netherlands
University Museum Utrecht
Netherlands

Keywords

Cholesterol, Dietary, Male, Cholesterol, Species Specificity, Esterases, Animals, Rats, Inbred Strains, Alkaline Phosphatase, Rats

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