Evolutionarily conserved regulation of TOR signalling
Copyright policy )Evolutionarily conserved regulation of TOR signalling
The target of rapamycin (TOR) is an evolutionarily conserved protein kinase that regulates cell growth in response to various environmental as well as intracellular cues through the formation of 2 distinct TOR complexes (TORC), TORC1 and TORC2. Dysregulation of TORC1 and TORC2 activity is closely associated with various diseases, including diabetes, cancer and neurodegenerative disorders. Over the past few years, new regulatory mechanisms of TORC1 and TORC2 activity have been elucidated. Furthermore, recent advances in the study of TOR inhibitors have revealed previously unrecognized cellular functions of TORC1. In this review, we briefly summarize the current understanding of the evolutionarily conserved TOR signalling from upstream regulators to downstream events.
- Nagoya University Japan
- University of Tokyo Japan
TOR Serine-Threonine Kinases, Mechanistic Target of Rapamycin Complex 2, Mechanistic Target of Rapamycin Complex 1, Lipids, Models, Biological, Evolution, Molecular, Multiprotein Complexes, Autophagy, Animals, Humans, RNA, Messenger, Ribosomes, Conserved Sequence, Signal Transduction
TOR Serine-Threonine Kinases, Mechanistic Target of Rapamycin Complex 2, Mechanistic Target of Rapamycin Complex 1, Lipids, Models, Biological, Evolution, Molecular, Multiprotein Complexes, Autophagy, Animals, Humans, RNA, Messenger, Ribosomes, Conserved Sequence, Signal Transduction
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