Dissemination of carbapenemase-producing Enterobacteriaceae in France, 2012
Copyright policy )Dissemination of carbapenemase-producing Enterobacteriaceae in France, 2012
Carbapenem-resistant Enterobacteriaceae isolates (n = 1485) were received at the French Associated National Reference Center for Antibiotic Resistance in 2012 and were characterized for their mechanism of resistance to carbapenems.Carbapenemase production was detected using the biochemical-based Carba NP test, based on the detection of in vitro hydrolysis of imipenem. All isolates with a positive Carba NP test result were characterized by PCR and sequencing.Carbapenemase production was identified in 23.1% of the isolates. The main carbapenemase type identified was OXA-48 and derivatives (75.5%). An overseas source was clearly demonstrated for only 27.6% of the isolates.OXA-48 and derivatives are now the most prevalent carbapenemases in France, with a possible spread of these producers in the community.
- University of Fribourg Switzerland
- French Institute of Health and Medical Research France
- Assistance Publique -Hopitaux De Paris France
- Bicêtre Hospital France
DNA, Bacterial, Enterobacteriaceae Infections, Sequence Analysis, DNA, Polymerase Chain Reaction, beta-Lactam Resistance, beta-Lactamases, Anti-Bacterial Agents, Bacterial Proteins, Carbapenems, Enterobacteriaceae, Humans, info:eu-repo/classification/udc/61, France
DNA, Bacterial, Enterobacteriaceae Infections, Sequence Analysis, DNA, Polymerase Chain Reaction, beta-Lactam Resistance, beta-Lactamases, Anti-Bacterial Agents, Bacterial Proteins, Carbapenems, Enterobacteriaceae, Humans, info:eu-repo/classification/udc/61, France
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