Emergence of Qnr determinants in human Salmonella isolates in Taiwan
Copyright policy )Emergence of Qnr determinants in human Salmonella isolates in Taiwan
The aim of this study was to determine the prevalence and characteristics of qnr-carrying Salmonella isolates from humans in southern Taiwan.A total of 446 Salmonella isolates collected between 2003 and 2006 were screened for qnrA, qnrB and qnrS by PCR experiments. Genetic structures of qnr were determined by PCR-based methods or direct sequencing of plasmid DNA.qnrB2 and qnrS1 were detected in two serovar Enteritidis isolates and two serovar Typhimurium isolates, respectively. One qnrS1-positive isolate was found to produce the CMY-2 AmpC enzyme. qnrS1 was identified on a 10 kb plasmid, which exhibited >99% nucleotide sequence identity with plasmid TPqnrS-1a reported from the UK. qnrB2 was found in a complex sul1-type class 1 integron on a >100 kb plasmid.This study demonstrated the occurrence of qnrB2 and qnrS1 in Salmonella for the first time in Taiwan and characterized their genetic structures.
- Centers for Disease Control and Prevention United States
- National Cheng Kung University Taiwan
DNA, Bacterial, Salmonella typhimurium, Molecular Sequence Data, Taiwan, Sequence Analysis, DNA, Quinolones, Polymerase Chain Reaction, Anti-Bacterial Agents, Bacterial Proteins, Salmonella enteritidis, Sequence Homology, Nucleic Acid, Drug Resistance, Bacterial, Salmonella Infections, Humans, Plasmids
DNA, Bacterial, Salmonella typhimurium, Molecular Sequence Data, Taiwan, Sequence Analysis, DNA, Quinolones, Polymerase Chain Reaction, Anti-Bacterial Agents, Bacterial Proteins, Salmonella enteritidis, Sequence Homology, Nucleic Acid, Drug Resistance, Bacterial, Salmonella Infections, Humans, Plasmids
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