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Amphotericin B tissue distribution in autopsy material after treatment with liposomal amphotericin B and amphotericin B colloidal dispersion

descriptionPublicationkeyboard_double_arrow_right Article 04 Apr 2006 English Publisher:Oxford University Press (OUP)Journal:Journal of Antimicrobial Chemotherapy, volume 57, pages 1,153-1,160 (issn: 0305-7453, eissn: 1460-2091,

Authors: Jordan Kountchev; Angela Djanani; Stefan Weiler; Helene Vogelsinger; Romuald Bellmann; Christian J. Wiedermann; Rosa Bellmann-Weiler;

doi: 10.1093/jac/dkl141

pmid: 16627591

Amphotericin B tissue distribution in autopsy material after treatment with liposomal amphotericin B and amphotericin B colloidal dispersion

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Abstract

Tissue concentrations of amphotericin B were determined in autopsy material of patients who had been treated with liposomal amphotericin B or amphotericin B colloidal dispersion (colloidal amphotericin B) for suspected or proven invasive fungal infection.Amphotericin B tissue levels were measured in liver, spleen, lung, kidney, and myocardial and brain tissue of 20 patients who had been treated with lipid-formulated amphotericin B, before they died from multi-organ failure. Seven patients had been treated with liposomal amphotericin B (AmBisome) and thirteen with colloidal amphotericin B (Amphocil). Tissue samples were obtained during routine autopsy, homogenized and extracted with methanol. Amphotericin B concentrations were measured using HPLC after purification by solid phase extraction.The highest amphotericin B levels were found in liver and spleen, followed by kidney, lung, myocardium and brain. In the lung higher amphotericin B concentrations were found after treatment with amphotericin B colloidal dispersion than after therapy with liposomal amphotericin B.The choice of lipid formulation may influence amphotericin B penetration into the lung.

Keywords

Adult, Brain Chemistry, Male, Tissue Extracts, Multiple Organ Failure, Myocardium, Middle Aged, Kidney, Liver, Mycoses, Amphotericin B, Humans, Female, Tissue Distribution, Autopsy, Lung, Chromatography, High Pressure Liquid, Spleen, Aged

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