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Antibodies. to Hepatitis B Core Antigen in Hepatitis B Surface Antigen-Positive and -Negative Chronic Hepatitis

Name: Antibodies. to Hepatitis B Core Antigen in Hepatitis B Surface Antigen-Positive and -Negative Chronic Hepatitis
Keywords: Adult, Cell Nucleus, Male, Hepatitis B Surface Antigens, Adolescent, Hepatitis, Viral, Human, Radioimmunoassay, Fluorescent Antibody Technique, Hemagglutination Tests, Middle Aged

descriptionPublicationkeyboard_double_arrow_right Article 01 Jun 1977 English Publisher:Oxford University Press (OUP)Journal:Journal of Infectious Diseases, volume 135, pages 1,006-1,009 (issn: 0022-1899, eissn: 1537-6613,

Authors: Teresa Zappi; Fiorenzo Paronetto; Michael A. Gerber; Salvatore J. Vernace;

doi: 10.1093/infdis/135.6.1006

pmid: 325149

Antibodies. to Hepatitis B Core Antigen in Hepatitis B Surface Antigen-Positive and -Negative Chronic Hepatitis

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Abstract

Antibody to hepatitis B core antigen (anti-HBc) is a sensitive indicator of hepatitis B virus (HBV) infection. However, anti-HBc has been found in only a few patients with chronic hepatitis. Therefore, we tested for anti-HBc in 124 sera from 67 patients with histologically proven chronic hepatitis by the indirect fluorescent antibody technique. All patients, except for one with chronic hepatitis who was seropositive for hepatitis B surface antigen (HBs Ag), had anti-HBc that persisted throughout the follow-up period (three months to three years). Of 33 HBs Ag-seronegative patients, anti-HBc was detected in seven patients and persisted for six months to two years. These findings suggest that in this study 21% of patients with chronic hepatitis with undetectable amounts of HBs Ag in the serum had evidence of recent or continued HBV replication.

Related Organizations

New York University
United States

Keywords

Adult, Cell Nucleus, Male, Hepatitis B Surface Antigens, Adolescent, Hepatitis, Viral, Human, Radioimmunoassay, Fluorescent Antibody Technique, Hemagglutination Tests, Middle Aged, Antibodies, Viral, Hepatitis B Core Antigens, Chronic Disease, Humans, Female, Aged, Autoantibodies

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	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%