A growing body of research has increasingly shed light on the mobility and systemic signaling roles of messenger RNAs (mRNAs). The field of plant grafting, especially horticultural crops, has provided scientists with the unique opportunity to identify thousands of mobile mRNAs. This, in turn, gives rise to a tantalizing question: What factors govern mRNA mobility?One prevailing model suggests that RNA mobility hinges on sequence-specific motifs, such as the epitranscriptomic RNA modification 5-methylcytosine (m5C) [1]. Yang et al. demonstrated a positive correlation between the number of m5C sites and mRNA mobility. Furthermore, they characterized two mRNAs influenced by m5C modification, namely TUMOR CONTROLLED TRRANSLATION PRPTEIN 1 (TCTP1) and HEAT SHOCK homologous protein 70.1 (HSC70.1). Importantly, the mobility of these mRNAs is governed by m5C modification and appears to be independent of their mRNA abundance [1]. It is worth noting, however, that m5C-modified mRNAs constitute only about 10% of the total mobile mRNA pool [1], suggesting the involvement of other factors besides m5C.