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Sialic acid activation

Name: Sialic acid activation
Creator: Edward L. Kean
Keywords: N-Acylneuraminate Cytidylyltransferase, Liver, Phosphoric Diester Hydrolases, Cytidine Monophosphate N-Acetylneuraminic Acid, Escherichia coli, Sialic Acids, Animals, Neisseria meningitidis

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 1991 English Publisher:Oxford University Press (OUP)Journal:Glycobiology, volume 1, pages 441-447 (issn: 0959-6658, eissn: 1460-2423,

Authors: Edward L. Kean;

doi: 10.1093/glycob/1.5.441

pmid: 1668304

Sialic acid activation

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Abstract

Cytidine 5'-monophosphosialic acid (CMP-sialic acid) is the activated form of sialic acid which is required for the biosynthesis of sialic acid-containing complex carbohydrates. Its discovery over 30 years ago by the laboratory of Dr Saul Roseman was a landmark in research dealing with the biosynthesis of these compounds. A review is presented of the salient features concerning this molecule: its discovery, chemistry, biosynthesis, subcellular location, enzymatic cleavage, transport and molecular biology. This report does not deal with its utilization by the sialyltransferases.

Related Organizations

Case Western Reserve University
United States

Keywords

N-Acylneuraminate Cytidylyltransferase, Liver, Phosphoric Diester Hydrolases, Cytidine Monophosphate N-Acetylneuraminic Acid, Escherichia coli, Sialic Acids, Animals, Neisseria meningitidis

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	76
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Average

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