SUMMARY Gravity gradient data can show the structural features of geological bodies in the shallow lithosphere with higher sensitivity and resolution than conventional gravity data. Gravity gradient inversion can be applied to obtain the lithospheric density structures of geological bodies. However, as with gravity data, gravity gradient data have no inherent depth resolution. The methods of gravity gradient depth imaging and gravity gradient inversion are integrated in this study. The depth imaging method is effective for calculations without prior information and iterative computations. As the parameters in the depth weighting function should be chosen from a set of values used in inversion tests of synthetic data, which brings some uncertainties, the depth imaging results of gravity gradient are introduced into the depth weighting function. Several synthetic models are tested to demonstrate the advantages and features of the effective integrated method. Finally, the integrated method is applied to the interpretation of the GOCE satellite gravity gradient tensors over the northeastern margin of the Qinghai–Tibet Plateau. The results reveal that in the crust of the study area, the distribution of density anomalies is more in line with the mechanism of the crustal flow model, in the upper mantle of the study area, the density anomalies are mainly influenced by the high heat flow environment.