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Genome Biology and Evolution
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Why Phenotype Robustness Promotes Phenotype Evolvability

Authors: Xinzhu Wei; Jianzhi Zhang;

Why Phenotype Robustness Promotes Phenotype Evolvability

Abstract

Robustness and evolvability are fundamental characteristics of life whose relationship has intrigued generations of biologists. Studies of several genotype-phenotype maps (GPMs) such as the map between short DNA sequences and their bindings to transcription factors showed that phenotype robustness (PR) promotes phenotype evolvability (PE), but the underlying reason is unclear. Here, we show mathematically that the expected PE is a monotonically increasing function of the expected PR in random GPMs. Population genetic simulations confirm that increasing PR raises the probability that a target phenotype appears in a population within a given time, under empirical as well as randomly rewired GPMs. These and other results demonstrate that the positive correlation between PR and PE is mathematical rather than biological. Hence, it is unsurprising to observe this correlation in every empirical GPM investigated, although the magnitude of the correlation may vary due to influences of various biological factors.

Keywords

Evolution, Molecular, Letter, Genetics, Population, Phenotype, Genotype, Models, Genetic, Mutation, Humans, Transcription Factors

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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
6
Average
Average
Average
Green
gold