Downloads provided by UsageCounts
Robustness is considered a ubiquitous property of living systems at all levels of organization, and small noncoding RNA (sncRNA) is a genuine model for its study at the molecular level. In this communication, we question whether microRNA precursors (pre-miRNAs) are actually structurally robust, as previously suggested. We found that natural pre-miRNAs are not more robust than expected under an appropriate null model. On the contrary, we found that eukaryotic pre-miRNAs show a significant enrichment in conformational flexibility at the thermal equilibrium of the molecule, that is, in their plasticity. Our results further support the selection for functional diversification and evolvability in sncRNAs.
Models, Molecular, Letter, secondary structure, Conformational flexibility, Noncoding RNA, thermodynamics, MicroRNAs, Secondary structure, RNA Precursors, Thermodynamics, Animals, Nucleic Acid Conformation, Evolvability, Non-coding RNA
Models, Molecular, Letter, secondary structure, Conformational flexibility, Noncoding RNA, thermodynamics, MicroRNAs, Secondary structure, RNA Precursors, Thermodynamics, Animals, Nucleic Acid Conformation, Evolvability, Non-coding RNA
| selected citations These citations are derived from selected sources. This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically). | 2 | |
| popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network. | Average | |
| influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically). | Average | |
| impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network. | Average |
| views | 82 | |
| downloads | 85 |

Views provided by UsageCounts
Downloads provided by UsageCounts