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Genome Biology and Evolution
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MicroRNA Precursors Are Not Structurally Robust but Plastic

Authors: Rodrigo Tarrega, Guillermo; Elena Fito, Santiago Fco;

MicroRNA Precursors Are Not Structurally Robust but Plastic

Abstract

Robustness is considered a ubiquitous property of living systems at all levels of organization, and small noncoding RNA (sncRNA) is a genuine model for its study at the molecular level. In this communication, we question whether microRNA precursors (pre-miRNAs) are actually structurally robust, as previously suggested. We found that natural pre-miRNAs are not more robust than expected under an appropriate null model. On the contrary, we found that eukaryotic pre-miRNAs show a significant enrichment in conformational flexibility at the thermal equilibrium of the molecule, that is, in their plasticity. Our results further support the selection for functional diversification and evolvability in sncRNAs.

Country
Spain
Keywords

Models, Molecular, Letter, secondary structure, Conformational flexibility, Noncoding RNA, thermodynamics, MicroRNAs, Secondary structure, RNA Precursors, Thermodynamics, Animals, Nucleic Acid Conformation, Evolvability, Non-coding RNA

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
views
OpenAIRE UsageCountsViews provided by UsageCounts
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2
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85
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