Gradually, it is becoming clear that our well-being depends significantly on the contribution and composition of microorganisms that are associated with us. The majority of human-associated microorganisms are bacteria, which maintain their niche through interactions with the human host and neighboring microorganisms. Secretory products contribute largely to maintaining their position in a complex ecosystem. The role of bacterial-released secreted RNA (seRNA) is mostly unexplored, and the study on seRNA will open a new branch in science. There are observations that have demonstrated the functional potential of seRNA, but more investigations are required to cover the entire path from their origin to function.