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DNA Research
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DNA Research
Article . 2025
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Satellite DNAs rising from the transposon graveyards

Authors: Eva Šatović-Vukšić; Patrik Majcen; Miroslav Plohl;

Satellite DNAs rising from the transposon graveyards

Abstract

Abstract Repetitive DNA sequences, as transposable elements (TEs) and satellite DNA (satDNA) spread and diversify within host genomes, impacting genome biology in numerous ways. In the first part of this review, we emphasize the evolutionary importance of satDNAs and TEs, providing a short summary of their roles and the mechanisms by which they influence the structure and function of genomes. We also discuss the broad, complex, and extensive relationships between TEs and satDNAs. Following that, we bring together different mechanisms on the generation of satDNA from TE, as it has been demonstrated that almost any part of any type of TE can undergo tandemization and produce novel satDNAs. Importantly, we here present a hypothesis that would explain the existence of particular types of monomers, namely composite satDNA monomers which display multiple subsequent stretches of similarity to various TEs, for which the explanation was lacking so far. We propose that even highly shuffled and degraded TE remnants residing in heterochromatin ‘TE graveyards’ can give rise to new satDNA sequence monomers, transforming these genomic loci into DNA ‘recycling yards’. Furthermore, we emphasize important evolutionary questions regarding the causes, mechanisms, and frequency of these occurrences.

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Keywords

Evolution, Molecular, heterochromatin, DNA Transposable Elements, Animals, Humans, Review, transposable elements, genome evolution, DNA, Satellite, satellite DNAs

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
1
Average
Average
Average
Green
gold