Synergism in the Folate Pathway

descriptionPublicationkeyboard_double_arrow_right Article 01 Mar 1982 English Publisher:Oxford University Press (OUP)Journal:Clinical Infectious Diseases, volume 4, pages 255-260 (issn: 1058-4838, eissn: 1537-6591,

Copyright policy )

Authors: R J, Harvey;

doi: 10.1093/clinids/4.2.255

pmid: 7051227

Synergism in the Folate Pathway

- Summary
- Subjects
- Metrics

Abstract

Synergism between inhibitors acting on different enzymes of a metabolic pathway can occur as a simple consequence of the nonlinear nature of normal enzyme kinetics. However, whether synergism does or does not occur is then determined entirely by the configuration of the pathway. Synergism between trimethoprim and sulfamethoxazole results from the cyclic configuration of the folate pathway.

Keywords

Kinetics, Folic Acid, Bacteria, Sulfamethoxazole, Terminology as Topic, Escherichia coli, Drug Interactions, Drug Synergism, Trimethoprim

Impact byBIP!

	selected citations These citations are derived from selected sources. This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	30
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Average
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Average