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Clinical Kidney Journal
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Clinical Kidney Journal
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Other literature type . 2021
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Roxadustat and thyroid-stimulating hormone suppression

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 20 Jan 2021 English Publisher:Oxford University Press (OUP)Journal:Clinical Kidney Journal, volume 14, pages 1,472-1,474 (eissn: 2048-8513, Copyright policy )
Authors: Tokuyama, Atsuyuki; Kadoya, Hiroyuki; Obata, Atsushi; Obata, Takahiro; Sasaki, Tamaki; Kashihara, Naoki;

doi: 10.1093/ckj/sfab007

pmid: 33959275

pmc: PMC8087136

Roxadustat and thyroid-stimulating hormone suppression

Abstract

Abstract Hypoxia-inducible factor prolyl-hydroxylase inhibitors belong to a new class of orally administered drugs for treating anemia in patients with chronic kidney disease (CKD). The prevalence of hypothyroidism is disproportionately high in patients with CKD on hemodialysis. We report a rapid suppression of thyroid-stimulating hormone (TSH) and decrease in free triiodothyronine (T3) and free tetraiodothyronine levels after switching from darbepoetin alfa to roxadustat in a hemodialysis patient with hypothyroidism on levothyroxine therapy. This was reversed after stopping roxadustat. Roxadustat has structural similarity with T3 and is a selective activating ligand for thyroid hormone receptor-β possibly suppressing TSH release.

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
32
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