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Cerebral Cortex
Article . 2019 . Peer-reviewed
License: CC BY NC
Data sources: Crossref
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Cerebral Cortex
Article
License: CC BY NC
Data sources: UnpayWall
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PubMed Central
Article . 2019
License: CC BY NC
Data sources: PubMed Central
Cerebral Cortex
Article . 2020
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Objective Morphological Classification of Neocortical Pyramidal Cells

Authors: Kanari L; Ramaswamy S; Shi Y; Morand S; Meystre J; Perin R; Abdellah M; +3 Authors

Objective Morphological Classification of Neocortical Pyramidal Cells

Abstract

A consensus on the number of morphologically different types of pyramidal cells (PCs) in the neocortex has not yet been reached, despite over a century of anatomical studies, due to the lack of agreement on the subjective classifications of neuron types, which is based on expert analyses of neuronal morphologies. Even for neurons that are visually distinguishable, there is no common ground to consistently define morphological types. The objective classification of PCs can be achieved with methods from algebraic topology, and the dendritic arborization is sufficient for the reliable identification of distinct types of cortical PCs. Therefore, we objectively identify 17 types of PCs in the rat somatosensory cortex. In addition, we provide a solution to the challenging problem of whether 2 similar neurons belong to different types or to a continuum of the same type. Our topological classification does not require expert input, is stable, and helps settle the long-standing debate on whether cell-types are discrete or continuous morphological variations of each other.

Keywords

neuronal classification, neuronal morphology, Lysine, Pyramidal Cells, Neocortex, Original Articles, Somatosensory Cortex, Pattern Recognition, Automated, Rats, topological data analysis, Imaging, Three-Dimensional, pyramidal cells, Animals, Supervised Machine Learning, rat somatosensory cortex

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    selected citations
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    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    79
    popularity
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    Top 1%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Top 1%
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
79
Top 1%
Top 10%
Top 1%
Green
hybrid