Yaws, caused by Treponema pallidum ssp. pertenue, is endemic in parts of West Africa, Southeast Asia and the Pacific. The WHO has launched a campaign based on mass treatment with azithromycin, to eradicate yaws by 2020.We reviewed published data, surveillance data and data presented at yaws eradication meetings.Azithromycin is now the preferred agent for treating yaws. Point-of-care tests have demonstrated their value in yaws.There is limited data from 76 countries, which previously reported yaws. Different doses of azithromycin are used in community mass treatment for yaws and trachoma.Yaws eradication appears an achievable goal. The programme will require considerable support from partners across health and development sectors.Studies to complete baseline mapping, integrate diagnostic tests into surveillance and assess the impact of community mass treatment with azithromycin are ongoing.