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British Medical Bulletin
Article . 2011 . Peer-reviewed
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Colorectal liver metastases

Authors: Robert P, Sutcliffe; Satyajit, Bhattacharya;

Colorectal liver metastases

Abstract

Despite major advances in therapies for liver metastases, colorectal cancer remains one of the commonest causes of cancer-related deaths in the UK.The international literature on the management of colorectal liver metastases (CLM) was reviewed.Due to a combination of highly active systemic agents and low perioperative mortality achieved by high-volume centres, a growing number of patients are being offered liver resection with curative intent. Patients with bilobar and/or extrahepatic disease who would previously have received palliative treatment only, are undergoing major surgery with good results. This review focuses on preoperative evaluation, surgical planning and the role of adjuvant therapies in the management of patients with CLM.Can ablative therapies match the outcomes of surgical resection? How can even more patients be rendered resectable?The use of other therapies, such as radiofrequency ablation and selective internal radiation therapy.New chemotherapy regimens for neo-adjuvant therapy and the development of new modalities of liver tumour ablation.

Keywords

Health Status, Brachytherapy, Liver Neoplasms, Antineoplastic Agents, Combined Modality Therapy, Neoadjuvant Therapy, Patient Care Planning, Clinical Protocols, Research Design, Preoperative Care, Catheter Ablation, Hepatectomy, Humans, Colorectal Neoplasms, Neoplasm Staging

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    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    6
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Average
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
6
Average
Average
Average
bronze
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Cancer Research