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Contamination of coagulation tests with heparin from blood gas samples

descriptionPublicationkeyboard_double_arrow_right Article 01 Oct 2001 United Kingdom English Publisher:Elsevier BVJournal:British Journal of Anaesthesia, volume 87, pages 628-629 (issn: 0007-0912,

Authors: Brown, Julian M; dimeski, g;

doi: 10.1093/bja/87.4.628

pmid: 11878734

handle: 1983/0f919213-fd32-445c-8160-bbf3a9fec56f

Contamination of coagulation tests with heparin from blood gas samples

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Abstract

We investigated the possibility that samples of blood could be contaminated by heparinized blood gas syringes, giving spurious results in coagulation tests. We collected coagulation test samples before (n=5) and after (n=13) blood gas sampling from a venous cannula in a volunteer. The results of activated partial thromboplastin time (APTT) tests were compared between control samples and samples taken before and after blood gas sampling. The median APTT after blood gas sampling was 71 s, significantly higher than before (median 34 s, P<0.05). We conclude that heparin from blood gas sampling syringes can contaminate coagulation tests. Heparinized samples for blood gas analysis should be obtained after coagulation test samples have been obtained.

Country

United Kingdom

Related Organizations

University of Bristol
United Kingdom
Princess Alexandra Hospital
Australia

Keywords

Blood Specimen Collection, Heparin, Anticoagulants, Humans, Partial Thromboplastin Time, Blood Gas Analysis, Diagnostic Errors

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