
doi: 10.1093/bja/79.4.514
pmid: 9389272
We have investigated the influence of a cold water bolus (CWB) injection on overestimation of cardiac output (CO) in low CO states in anaesthetized dogs. CO was measured using three methods: (1) thermodilution (TD), (2) electromagnetic (EM) flow meter placed on the pulmonary artery and (3) transoesophageal echo-Doppler (OD) placed on the descending aorta. Measurements of CO were obtained before (steady state) and after induction of a low CO state with thiopentone 5 mg kg-1 i.v. After CWB injection, mean CO measured by EM and OD increased by 26% and 27%, respectively (P < 0.05) during steady state, and by 85% and 75% (P < 0.05) during the low CO state. This transient increase was produced by an increase in stroke volume, while heart rate did not change. Frank Starling's law may explain this variation by a sudden increase in preload produced by CWB injection. These results indicate that thermodilution overestimated CO during low CO states when CWB injection was used.
Cold Temperature, Dogs, Hemorheology, Thermodilution, Cardiac Output, Low, Animals, Aorta, Thoracic, Pulmonary Artery, Electromagnetic Phenomena, Echocardiography, Doppler, Echocardiography, Transesophageal
Cold Temperature, Dogs, Hemorheology, Thermodilution, Cardiac Output, Low, Animals, Aorta, Thoracic, Pulmonary Artery, Electromagnetic Phenomena, Echocardiography, Doppler, Echocardiography, Transesophageal
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