Effect of tramadol on depth of anaesthesia
Copyright policy )Effect of tramadol on depth of anaesthesia
We have studied 51 patients who were anaesthetized with propofol and suxamethonium followed by 0.7% isoflurane and 66% nitrous oxide in oxygen to see if tramadol caused lightening of anaesthesia. A two-channel EEG was recorded and music was played via headphones. Two groups received tramadol 200 and 100 mg i.v. and the third group received saline. Tramadol caused significant, dose-dependent activation of the EEG, evidenced by increased frequencies and decreased amplitudes, but these changes were small and probably unimportant. Derived EEG variables did not approach values known to be associated with near-awakening during isoflurane anaesthesia. No patient moved on skin incision and there were no incidences of free recall.
- Stellenbosch University South Africa
- University of the Witwatersrand South Africa
recall, Nitrous Oxide, arousal, dose response, Anesthesia, Drug Interactions, Propofol, Tramadol, Analgesics, nitrous oxide, Isoflurane, adult, drug effect, article, clinical trial, Electroencephalography, Middle Aged, anesthesia level, intravenous drug administration, Analgesics, Opioid, aged, priority journal, Inhalation, sodium chloride, Anesthetics, Inhalation, Drug, tramadol, Adult, Adolescent, suxamethonium, 610, Succinylcholine, Opioid, Dose-Response Relationship, isoflurane, 617, Humans, controlled study, music, human, Anesthetics, Aged, skin incision, propofol, controlled clinical trial, Dose-Response Relationship, Drug, electroencephalogram, major clinical study, randomized controlled trial, Mental Recall, Anesthesia, Inhalation, oxygen
recall, Nitrous Oxide, arousal, dose response, Anesthesia, Drug Interactions, Propofol, Tramadol, Analgesics, nitrous oxide, Isoflurane, adult, drug effect, article, clinical trial, Electroencephalography, Middle Aged, anesthesia level, intravenous drug administration, Analgesics, Opioid, aged, priority journal, Inhalation, sodium chloride, Anesthetics, Inhalation, Drug, tramadol, Adult, Adolescent, suxamethonium, 610, Succinylcholine, Opioid, Dose-Response Relationship, isoflurane, 617, Humans, controlled study, music, human, Anesthetics, Aged, skin incision, propofol, controlled clinical trial, Dose-Response Relationship, Drug, electroencephalogram, major clinical study, randomized controlled trial, Mental Recall, Anesthesia, Inhalation, oxygen
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