A MODEL TO TEST THE POTENCY OF INHALATION ANAESTHETICS
Copyright policy )A MODEL TO TEST THE POTENCY OF INHALATION ANAESTHETICS
The water flea Daphnia magna was studied as a potential model of the potency of inhalation anaesthetics in humans. Anaesthesia was defined as lack of movement to a noxious stimulus (strong light). Effective concentrations which produced anaesthesia of 50% of the individuals (EC50) for halothane, isoflurane and enflurane were 1.006, 1.156 and 1.415, respectively. Anaesthesia was reversible rapidly. It is suggested that Daphnia should replace vertebrates in early studies of inhalation anaesthetic potency.
- University of Sheffield United Kingdom
Enflurane, Daphnia, Dose-Response Relationship, Drug, Isoflurane, Light, Movement, Animals, Anesthesia, Inhalation, Halothane, Models, Biological
Enflurane, Daphnia, Dose-Response Relationship, Drug, Isoflurane, Light, Movement, Animals, Anesthesia, Inhalation, Halothane, Models, Biological
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).9 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Average
Citations provided by BIP!Popularity provided by BIP!