Histone acetylation in gene regulation
Copyright policy )Histone acetylation in gene regulation
Genetic information is packaged in the highly dynamic nucleoprotein structure called chromatin. Many biological processes are regulated via post-translational modifications of key proteins. Acetylation of lysine residues at the N-terminal histone tails is one of the most studied covalent modifications influencing gene regulation in eukaryotic cells. This review focuses on the role of enzymes involved in controlling both histone and non-histone proteins acetylation levels in the cell, with particular emphasis on their effects on cancer.
- National Research Council Sri Lanka
- Roma Tre University Italy
- Sapienza University of Rome Italy
- Institute of Molecular Biology and Pathology Italy
- National Research Council Italy
Acetylation, Models, Biological, Chromatin, Histone Deacetylases, Epigenesis, Genetic, Histone Deacetylase Inhibitors, Histones, nucleosomes; gene expression; acetylation; deacetylation; cancer, Gene Expression Regulation, Neoplasms, Animals, Humans, Protein Processing, Post-Translational, Histone Acetyltransferases
Acetylation, Models, Biological, Chromatin, Histone Deacetylases, Epigenesis, Genetic, Histone Deacetylase Inhibitors, Histones, nucleosomes; gene expression; acetylation; deacetylation; cancer, Gene Expression Regulation, Neoplasms, Animals, Humans, Protein Processing, Post-Translational, Histone Acetyltransferases
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