Diallyl Trisulfide attenuates alcohol-induced hepatocyte pyroptosis via elevation of hydrogen sulfide

descriptionPublicationkeyboard_double_arrow_right Article 07 Sep 2022 English Publisher:Oxford University Press (OUP)Journal:Bioscience, Biotechnology, and Biochemistry, volume 86, pages 1,552-1,561 (eissn: 1347-6947,

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Authors: Xiaojing Zhu; Rongxin Lu; Genrong Zhang; Ling Fan; Yongjiu Zhan; Guoxin Chen; Liang Zhou;

doi: 10.1093/bbb/zbac149

pmid: 36073357

Diallyl Trisulfide attenuates alcohol-induced hepatocyte pyroptosis via elevation of hydrogen sulfide

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Abstract

ABSTRACTGarlic is a popular culinary herb for the prevention and treatment of alcoholic liver disease (ALD). Diallyl Trisulfide (DATS) is the major organosulfur compound of garlic. Latest studies indicated that the hepatocyte pyroptosis serves a primary role in the pathogenesis of ALD. The present study aims to assess the inhibitory effect of DATS on alcohol-induced hepatocyte pyroptosis, and to elucidate the potential mechanism by using the hepatocyte cell line HL-7702. Our study found that DATS inhibited alcohol-induced pyroptosis by decreasing gasdermin D (GSDMD) activation. Results illuminated that DATS inhibited alcohol-induced (NOD)-like receptor containing pyrin domain 3 (NLRP3) inflammasome activation by reducing intracellular reactive oxygen species (ROS) accumulation. Furthermore, DATS upregulated hydrogen sulfide (H2S) to resist ROS overproduction. The present study demonstrated that DATS mitigated alcohol-induced hepatocyte pyroptosis by increasing the intracellular level of H2S.

Related Organizations

Nanjing University of Chinese Medicine
China (People's Republic of)
Suzhou Traditional Chinese Medicine Hospital
China (People's Republic of)

Keywords

Ethanol, Inflammasomes, Apoptosis, Sulfides, Antioxidants, Allyl Compounds, NLR Family, Pyrin Domain-Containing 3 Protein, Pyroptosis, Hepatocytes, Hydrogen Sulfide, Reactive Oxygen Species, Garlic

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