In vitro selection of an RNA aptamer yields an interleukin-6/interleukin-6 receptor interaction inhibitor
Copyright policy )In vitro selection of an RNA aptamer yields an interleukin-6/interleukin-6 receptor interaction inhibitor
ABSTRACT Interleukin-6 (IL-6) binds to the IL-6 receptor (IL-6R) subunit, related to autoimmune diseases and cytokine storm in COVID-19. In this study, we performed systematic evolution of ligands by exponential enrichment and identified a novel RNA aptamer. This RNA aptamer not only bound to IL-6R with a dissociation constant of 200 n m, but also inhibited the interaction of IL-6R with IL-6.
- University of Yamanashi Japan
- National Presto Industries United States
- Japan Science and Technology Agency Japan
Base Sequence, Interleukin-6, Organic Chemistry, SELEX Aptamer Technique, COVID-19, General Medicine, Aptamers, Nucleotide, Applied Microbiology and Biotechnology, Biochemistry, Receptors, Interleukin-6, Analytical Chemistry, COVID-19 Drug Treatment, DNA, Viral, Interleukin-6 Inhibitors, Humans, Cytokine Release Syndrome, Molecular Biology, Biotechnology
Base Sequence, Interleukin-6, Organic Chemistry, SELEX Aptamer Technique, COVID-19, General Medicine, Aptamers, Nucleotide, Applied Microbiology and Biotechnology, Biochemistry, Receptors, Interleukin-6, Analytical Chemistry, COVID-19 Drug Treatment, DNA, Viral, Interleukin-6 Inhibitors, Humans, Cytokine Release Syndrome, Molecular Biology, Biotechnology
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