Novel Nuclear Signaling Pathway Mediates Activation of Fibroblast Growth Factor-2 Gene by Type 1 and Type 2 Angiotensin II Receptors
Copyright policy )Novel Nuclear Signaling Pathway Mediates Activation of Fibroblast Growth Factor-2 Gene by Type 1 and Type 2 Angiotensin II Receptors
In bovine adrenal medullary cells synergistically acting type 1 and type 2 angiotensin II (AII) receptors activate the fibroblast growth factor-2 (FGF-2) gene through a unique AII-responsive promoter element. Both the type 1 and type 2 AII receptors and the downstream cyclic adenosine 1′,3′-monophosphate- and protein kinase C-dependent signaling pathways activate the FGF-2 promoter through a novel signal-transducing mechanism. This mechanism, which we have named integrative nuclear FGF receptor-1 signaling, involves the nuclear translocation of FGF receptor-1 and its subsequent transactivation of the AII-responsive element in the FGF-2 promoter.
- State University of New York United States
- Arizona State University United States
- University of Pennsylvania United States
- State University of New York at Potsdam United States
- Scripps Research Institute United States
Cell Nucleus, Binding Sites, Receptors, Angiotensin, Pyridines, Angiotensin II, DNA Footprinting, Imidazoles, Response Elements, Receptor, Angiotensin, Type 2, Receptor, Angiotensin, Type 1, Recombinant Proteins, Gene Expression Regulation, Adrenal Medulla, Animals, Deoxyribonuclease I, Cattle, Fibroblast Growth Factor 2, Promoter Regions, Genetic, Cells, Cultured, Signal Transduction
Cell Nucleus, Binding Sites, Receptors, Angiotensin, Pyridines, Angiotensin II, DNA Footprinting, Imidazoles, Response Elements, Receptor, Angiotensin, Type 2, Receptor, Angiotensin, Type 1, Recombinant Proteins, Gene Expression Regulation, Adrenal Medulla, Animals, Deoxyribonuclease I, Cattle, Fibroblast Growth Factor 2, Promoter Regions, Genetic, Cells, Cultured, Signal Transduction
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