Association Between BKPyV Serotype I Antibody Level and Natalizumab-Associated Progressive Multifocal Leukoencephalopathy
Copyright policy )Association Between BKPyV Serotype I Antibody Level and Natalizumab-Associated Progressive Multifocal Leukoencephalopathy
To determine the association between BK polyomavirus (BKPyV) types 1 and 4 capsid antibody and natalizumab-associated progressive multifocal leukoencephalopathy (PML) in patients with multiple sclerosis (MS), serum samples were obtained from 10 natalizumab-associated PML cases and 130 control MS patients treated with natalizumab, and 82 control MS patients never exposed to natalizumab. In a sex- and age-adjusted regression model, BKPyV serotype 1 antibody levels were significantly higher in natalizumab-treated controls (p = 0.009) compared with cases, and were higher in controls never treated with natalizumab compared with cases, but the difference did not reach statistical significance (p = 0.158). There was no association between BKPyV serotype 4 antibody and PML. We hypothesize that a robust immune response to BKPyV may be protective against the development of PML.
- Johns Hopkins Medicine United States
- Roma Tre University Italy
- JOHNS HOPKINS UNIVERSITY United States
- Sapienza University of Rome Italy
- Vita-Salute San Raffaele University Italy
Adult, Male, Polyomavirus Infections, Multiple Sclerosis, Natalizumab, Age Factors, Leukoencephalopathy, Progressive Multifocal, Middle Aged, Antibodies, Viral, Serogroup, JC Virus, Sex Factors, BK Virus, Humans, Regression Analysis, BKPyV; JCPyV; multiple sclerosis; natalizumab; PML; Immunology; Molecular Medicine; Virology, Female
Adult, Male, Polyomavirus Infections, Multiple Sclerosis, Natalizumab, Age Factors, Leukoencephalopathy, Progressive Multifocal, Middle Aged, Antibodies, Viral, Serogroup, JC Virus, Sex Factors, BK Virus, Humans, Regression Analysis, BKPyV; JCPyV; multiple sclerosis; natalizumab; PML; Immunology; Molecular Medicine; Virology, Female
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