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Podoplanin Expression in Canine Melanoma

descriptionPublicationkeyboard_double_arrow_right Article 01 Dec 2016 English Publisher:Mary Ann Liebert IncJournal:Monoclonal Antibodies in Immunodiagnosis and Immunotherapy, volume 35, pages 304-306 (eissn: 2167-9436,

Authors: Ryusuke Honma; Yumiko Kagawa; Satoru Konnai; Yuki Fujii; Mika K. Kaneko; Yukinari Kato; Satoshi Ogasawara;

doi: 10.1089/mab.2016.0040

pmid: 27918691

pmc: PMC5206701

Podoplanin Expression in Canine Melanoma

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Abstract

A type I transmembrane protein, podoplanin (PDPN), is expressed in several normal cells such as lymphatic endothelial cells or pulmonary type I alveolar cells. We recently demonstrated that anticanine PDPN monoclonal antibody (mAb), PMab-38, recognizes canine PDPN of squamous cell carcinomas, but does not react with lymphatic endothelial cells. Herein, we investigated whether PMab-38 reacts with canine melanoma. PMab-38 reacted with 90% of melanoma cells (9/10 cases) using immunohistochemistry. Of interest, PMab-38 stained the lymphatic endothelial cells and cancer-associated fibroblasts in melanoma tissues, although it did not stain any lymphatic endothelial cells in normal tissues. PMab-38 could be useful for uncovering the function of PDPN in canine melanomas.

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Keywords

Membrane Glycoproteins, Antibodies, Monoclonal, Endothelial Cells, Gene Expression, Immunohistochemistry, Dogs, Cancer-Associated Fibroblasts, Antibody Specificity, Animals, Mouth Neoplasms, Dog Diseases, Melanoma

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