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Journal of Computational Biology
Article . 2018 . Peer-reviewed
License: Mary Ann Liebert TDM
Data sources: Crossref
DBLP
Article . 2018
Data sources: DBLP
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A Flow Procedure for Linearization of Genome Sequence Graphs

Authors: David Haussler; Maciej Smuga-Otto; Jordan M. Eizenga; Benedict Paten; Adam M. Novak; Sergei Nikitin; Maria Zueva; +1 Authors

A Flow Procedure for Linearization of Genome Sequence Graphs

Abstract

Efforts to incorporate human genetic variation into the reference human genome have converged on the idea of a graph representation of genetic variation within a species, a genome sequence graph. A sequence graph represents a set of individual haploid reference genomes as paths in a single graph. When that set of reference genomes is sufficiently diverse, the sequence graph implicitly contains all frequent human genetic variations, including translocations, inversions, deletions, and insertions. In representing a set of genomes as a sequence graph, one encounters certain challenges. One of the most important is the problem of graph linearization, essential both for efficiency of storage and access, and for natural graph visualization and compatibility with other tools. The goal of graph linearization is to order nodes of the graph in such a way that operations such as access, traversal, and visualization are as efficient and effective as possible. A new algorithm for the linearization of sequence graphs, called the flow procedure (FP), is proposed in this article. Comparative experimental evaluation of the FP against other algorithms shows that it outperforms its rivals in the metrics most relevant to sequence graphs.

Country
United States
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Keywords

Bioinformatics, Bioinformatics and Computational Biology, Translocation, Mathematical sciences, linearization, Mathematical Sciences, Translocation, Genetic, Genetic, Information and Computing Sciences, 616, backbone, Genetics, Humans, flow procedure, grooming, Genome, sequence graph, Base Sequence, Genome, Human, Human Genome, Chromosome Mapping, Computational Biology, Genomics, Biological Sciences, sequence graph., 004, Biological sciences, Information and computing sciences, feedback arcs, Algorithms, Human, cut width

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
3
Average
Average
Average
Green
bronze