LncRNA NR2F1-AS1 Regulates miR-371a-3p/TOB1 Axis to Suppress Proliferation of Colorectal Cancer Cells
Copyright policy )LncRNA NR2F1-AS1 Regulates miR-371a-3p/TOB1 Axis to Suppress Proliferation of Colorectal Cancer Cells
A recent study reported the oncogenic function of lncRNA NR2F1-AS1 in liver cancer. Interestingly, by analyzing TCGA data set, downregulation of NR2F1-AS1 in colorectal cancer (CRC) was observed. This observation triggered interest to analyze the functions of NR2F1-AS1 in CRC. It was observed that NR2F1-AS1 was downregulated in CRC and predicted poor survival. NR2F1-AS1 can directly interact with miR-371a-3p but their overexpression failed to affect the expression of each other. However, NR2F1-AS1 overexpression led to the upregulation of TOB1, a target of miR-371a-3p. Cell proliferation analysis revealed reduced proliferation rate of CRC cells after NR2F1-AS1 and TOB1 overexpression. MiR-371a-3p overexpression played an opposite role and reduced the effects of NR2F1-AS1 and TOB1 overexpression. In conclusion, NR2F1-AS1 regulates miR-371a-3p/TOB1 axis to suppress proliferation of CRC cells.
- Henan Polytechnic University China (People's Republic of)
- First Affiliated Hospital of Henan University of Science and Technology China (People's Republic of)
Adult, COUP Transcription Factor I, Tumor Suppressor Proteins, Intracellular Signaling Peptides and Proteins, Middle Aged, MicroRNAs, Humans, RNA, Antisense, RNA, Long Noncoding, Colorectal Neoplasms, Aged, Cell Proliferation
Adult, COUP Transcription Factor I, Tumor Suppressor Proteins, Intracellular Signaling Peptides and Proteins, Middle Aged, MicroRNAs, Humans, RNA, Antisense, RNA, Long Noncoding, Colorectal Neoplasms, Aged, Cell Proliferation
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