Today's biomedical research of excellence is mainly seen as a global phenomenon around the study of large series of samples organized with well-defined and detailed criteria regarding the identification of patients, with the specific information required in each case. This justifies the growing interest in developing cooperative networks of biobanks to minimize biases arising from heterogeneity in the quality of biological samples by means of protocols for procedures, development of common quality assurance policies, and promotion of collaborative environments. This article focuses on some basic aspects of biobank networking, including design and management. It does not try to be an exhaustive analysis but a preliminary approach to the topic, based on the author's expertise in biobank networking in Spain.