Abstract The article describes the developed engineering technological measures. They increase the operation life of road structures with the use of technogenic non-toxic materials. It is recommended to use activating additives to accelerate the process of road mixtures hardening. The introduction of gypsum anhydrite waste in an amount of 5 % into the crushed-nepheline road mixtures provides an increase in their strength characteristics by 1.8–2.2 times and increases the frost resistance of the road surface. This allows recommending the developed structure of region road pavement in regions with an average monthly air temperature of the coldest month from -15oC to-30oC. The conducted industrial tests of the proposed engineering technological measures confirmed the results of the research and provided their practical implementation in the technology of laying the lower base of the road pavement.