This article provides a coarse-grained review on the experimental tests of fundamental discrete symmetries, focusing on those which appear to be deeply ingrained in nature, or at least rooted into the description of it which we are currently capable of providing, namely those related to space-time inversions and particle/anti-particle exchange. A broad selection of tests is discussed, not in the (vain) pursuit of completeness, but rather with the aim of providing an overview of the variety of approaches, and of the underlying common principles.