D-branes are classified by twisted K-theory. Yet twisted K-theory is often hard to calculate. We argue that, in the case of a compactification on a simply-connected six manifold, twisted K-theory is isomorphic to a much simpler object, twisted homology. Unlike K-theory, homology can be twisted by a class of any degree and so it classifies not only D-branes but also M-branes. Twisted homology classes correspond to cycles in a certain bundle over spacetime, and branes may decay via Kachru-Pearson-Verlinde transitions only if this cycle is trivial. We provide a spectral sequence which calculates twisted homology, the kth step treats D(p-2k)-branes ending on Dp-branes.

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